During the testing of dehydrated food, Jerry knocks over a cup in the process, resulting in the food going all over the place in an explosion. In the process, Tom and Jerry are caught during the speech (first misunderstood as aliens due to Tom getting hit by green paint backstage) and the staff try to capture them, but only Tom is caught and thrown out. Tom chases Jerry as usual from their house and across town until they arrive at the 'International Space Place', where astronauts Buzz Blister and Biff Buzzard are heading to Mars.

It is Joseph Barbera's first solo Tom and Jerry work without his partner William Hanna, who died on March 22, 2001.

Alongside Tom and Jerry: The Fast and the Furry (also written and directed by Bill Kopp), the release of the film coincided with the 65th anniversary of the cat-and-mouse team's debut in 1940. The film was released on DVD and VHS on January 18, 2005, and on Blu-ray on October 16, 2012. With both the pre-production and post-production processes being based in the United States, it was animated by Filipino-based Toon City in Manila, Philippines.

Animation and Turner Entertainment Co., it is the second made-for-video Tom and Jerry film.

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